Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population
Authors' conclusion
Women in the first trimester of pregnancy had significantly higher NT-proBNP than those in the third trimester and compared to similarly aged nonpregnant women.
Study context
- Population
- Women aged 20 to 40 years without a history of CVD, NHANES 1999 to 2004546 pregnant
- Participants
- 2,134 women
- Exposure
- NT-proBNP by pregnancy status and trimester
- Outcome
- Prevalence of elevated NT-proBNP (>125 pg/mL)
Methodological detailsnationally representative sample (NHANES 1999–2004)
- Nationally representative sample (NHANES 1999–2004)
Main finding
As reported in the abstract
Elevated NT-proBNP (>125 pg/mL)
Observational data: associations, not effects.
Further findings
| Outcome | Absolute difference (pg/mL) (95% CI) | |
|---|---|---|
| Adjusted NT-proBNP levelFirst trimestervs Nonpregnant44% higher; adjusted for demographics and CV risk factors | 26.4 (11.2–41.6) | |
| Adjusted NT-proBNP levelThird trimestervs First trimester46% lower; pregnant women only | −22.2 (−36.9 to −7.5) | |
| −40−200204060Difference, pg/mL (linear scale) |
Correlates of NT-proBNP
- NT-proBNP inversely associated with BMI and SBP
Original publication
Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population. JACC Adv. Published 8 March 2023. doi:10.
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