Aortic & peripheral vascular diseaseCohort study
Prevalence and predictors of extra-aortic aneurysms in Marfan syndrome
- multicentre retrospective cohort study
- three tertiary centres
- systematic chart and imaging adjudication
Authors' conclusion
Extra-aortic vascular involvement is common in Marfan syndrome and closely linked to advanced aortic pathology. These findings support risk-stratified vascular imaging beyond the thoracic aorta in higher-risk patients.
Study context
- Population
- Patients with Marfan syndromepatients with Marfan syndrome across three tertiary centres
- Participants
- 783 patients
Main finding
As reported in the abstract
Extra-aortic aneurysms
Prevalence of extra-aortic aneurysms
32%
Observational data: associations, not effects.
Further findings
Extra-aortic dissections
- Prevalence of extra-aortic dissections
- 5.2%
Factors associated with extra-aortic aneurysms
- abdominal aortic aneurysm (adjusted OR)
- 3.48
- prior aortic dissection (OR)
- 3.39
- extra-aortic dissection (OR)
- 4.44
- age >40 years
- male sex
- comparator groups for the ORs not printed
Genetic confirmation status and extra-aortic aneurysm presence
- Genetic confirmation status was not associated with extra-aortic aneurysm presence
Original publication
Prevalence and predictors of extra-aortic aneurysms in Marfan syndrome. Heart. Published 8 May 2026. doi:10.1136/heartjnl-2025-327408
Summarised from the published abstract; every number is checked against it