Valvular & structural heart disease

Prevalence and clinical significance of masquerading bundle branch block in patients undergoing transcatheter aortic valve replacement: Insights from a single-center registry

Heart RhythmPublished Retrospective cohort study

Authors' conclusion

MBBB is not rare in TAVR candidates, occurring in approximately 8% of pre-TAVR ECGs labeled as RBBB.

Study context

Population
Consecutive TAVR patients, single-centre database, 2010–2023of 1085 screened
Participants
980 patients
Exposure
Masquerading bundle branch block (MBBB) vs right bundle branch block (RBBB) vs Left bundle branch block
  • MBBBn = 13
  • RBBBn = 151reference
  • Left bundle branch blockn = 158
Outcome
Prevalence of MBBB on pre-TAVR ECG and pacemaker implantation
Follow-up
Within 30 days
Methodological detailssingle-centre, registry, consecutive patients, blinded electrocardiographic (ECG) classification
  • Single-centre
  • Registry
  • Consecutive patients
  • Blinded ECG classification

Main finding

As reported in the abstract

Prevalence of conduction abnormalities on pre-TAVR ECG
All MBBB cases initially mislabelled as RBBB, share of that group
7.9%

Observational data: associations, not effects.

Further findings

OutcomeMBBBRBBB
Early pacemaker implantation · within 30 days92.5%44.3%
Early pacemaker implantation — All patients
166 (16.9%)
Death or HF hospitalisation (MBBB) · 1 year after TAVR
38%

Original publication

Prevalence and clinical significance of masquerading bundle branch block in patients undergoing transcatheter aortic valve replacement: Insights from a single-center registry. Heart Rhythm. Published 6 November 2025. doi:10.1016/j.hrthm.2025.11.004

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