Valvular & structural heart diseaseResearch article
Race and Ethnic-Specific Burden of Aortic Valve Calcium and Its Association With Long-Term Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis
- Multi-Ethnic Study of Atherosclerosis
- multivariable Cox proportional hazards
- Aortic valve calcium (AVC) scores were not reported to participants
Authors' conclusion
The racial and ethnic groups with a higher baseline prevalence of AVC had a higher long-term incidence of moderate-severe AS, but a similar relative association between AVC and moderate-severe AS regardless of baseline atherosclerotic cardiovascular disease risk. Our findings suggest that differences in AS by race and ethnicity may likely be explained by the burden of AVC.
Study context
- Population
- MESA participants with baseline AVC quantified by the Agatston methodMESA participants with baseline AVC quantified
- Participants
- 6,812 participants
- Comparison
- Association of log-transformed AVC with moderate-severe aortic stenosis (AS) for each race and ethnicity
- Outcome
- Long-term moderate or severe AS
- Follow-up
- Median 16.7 years
Main finding
As reported in the abstract
White
2.1/1000 person-years
rate
Chinese
0.5/1000 person-years
rate
Hazard ratio, per 1 unit higher log transformed AVC (95% CI)
White
1.82(1.62–2.03)
Hispanic
2.18(1.82–2.62)
Black
2.28(1.78–2.93)
Chinese
3.65(1.05–12.71)
Per 1 unit higher log transformed AVC, as printed
- Diagnosed with moderate and severe AS
- 140
- Moderate AS
- n=56
- Severe AS
- n=84
Further findings
Prevalence of baseline AVC >0
- Prevalence of baseline AVC >0 — Mean age
- 62 years
- Prevalence of baseline AVC >0 — Women
- 47%
Original publication
Race and Ethnic-Specific Burden of Aortic Valve Calcium and Its Association With Long-Term Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. Published 28 January 2026. doi:10.1161/circimaging.125.018916
Summarised from the published abstract; every number is checked against it