Congenital heart disease

Prevalence of Intracranial Aneurysms in Patients With Coarctation of the Aorta: A Systematic Review and Meta-Analysis

JACC AdvPublished Systematic review and meta-analysis of cohort studies

Authors' conclusion

The development of IAs is likely multifactorial in etiology and there may be modifiable RFs in their development.

Study context

Population
Patients with coarctation of the aorta screened for intracranial aneurysms by CT or MR angiography
Participants
442 patients5 cohort studies
Outcome
Prevalence of intracranial aneurysms

Pooled result

As reported in the abstract

Pooled prevalence of intracranial aneurysms

Coarctation of the aorta (CoA)

3.8%

95% CI 0.1%–12.3%

Further pooled results

Risk factors for intracranial aneurysms (5 evaluated): hypertension

OR (95% CI)P value
HypertensionOnly RF associated with IAs3.1 (1.1–8.2)P = 0.03

Prevalence of intracranial aneurysms over time

Downward trend over time in prevalence among included studies

Original publication

Prevalence of Intracranial Aneurysms in Patients With Coarctation of the Aorta: A Systematic Review and Meta-Analysis. JACC Adv. Published 5 July 2023. doi:10.1016/j.jacadv.2023.100394

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