Prognostic value of left atrial stiffness index in adults with repaired coarctation of aorta
Authors' conclusion
LA stiffness index improves prognostication in adults with COA and can potentially be used to guide timing of intervention or monitor response to therapy.
Study context
- Population
- Adults with repaired coarctation of aorta (COA)patients [age 36 ± 16 years, males 437 (60%)]
- Participants
- 729 adults
- Comparison
- High left atrial (LA) stiffness index vs. low LA stiffness index groups
- Outcome
- Correlation of LA stiffness index with right ventricular to pulmonary artery (RV-PA) coupling
Main finding
As reported in the abstract
R
−0.56
P
P < 0.001
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Heart failure hospitalizationAdjusted | 3.17 (1.84–7.36) | P = 0.007 | |
| All-cause mortalityAdjusted | 2.81 (1.28–12.32) | P = 0.005 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Correlation of LA stiffness index with NT-proBNP
- R
- 0.62
- P
- P < 0.001
Correlation of LA stiffness index with predicted peak VO2
- R
- −0.51
- P
- P < 0.001
Prognostic performance of LA stiffness index for heart failure hospitalization · 5-year
- AUC
- 0.803
- 95% CI
- 0.756-0.849
- P
- P < 0.001
- Superior compared with conventional echocardiographic indices of left heart diastolic function
Prognostic performance of LA stiffness index for all-cause mortality · 5-year
- AUC
- 0.786
- 95% CI
- 0.742-08.30
- P
- P < 0.001
- Superior compared with conventional echocardiographic indices of left heart diastolic function
Original publication
Prognostic value of left atrial stiffness index in adults with repaired coarctation of aorta. Eur Heart J Cardiovasc Imaging. Published 30 December 2025. doi:10.
Summarised from the published abstract; every number is checked against it