Prevalence of Subclinical Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction

Yang, E; Heckbert, SR; Ding, J; Spragg, D; Calkins, H; Shah, S; Szklo, M; Post, WS; Sharma, K

doi:10.1016/j.jchf.2023.09.023

Heart failure & cardiomyopathies

Prevalence of Subclinical Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction

JACC Heart FailPublished 22 Nov 2023Cross-sectional study

Main finding · Subclinical AFResultOdds ratio 3.01 95% CI 1.13–7.99

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Authors' conclusion

Patients with HFpEF had a higher prevalence of subclinical AF than participants without HF from a community-based study.

Study context

Population: Patients with heart failure with preserved ejection fraction (HFpEF) without prior atrial fibrillation (AF) vs community controls without HF (MESA), same ECG monitoring
Participants: 90 vs 1,230

Exposure: HFpEF vs non-HF MESA participants
HFpEFn = 90
MESAn = 1,230reference
Outcome: Prevalence of subclinical AF

Main finding

Subclinical AF

Odds ratio

3.01

95% CI 1.13–7.99

P = 0.03

By group

HFpEF8.9%

MESA4.1%

HFpEFvs MESA

OR 3.01 (95% CI 1.13–7.99); P = 0.03

As reported in the abstract

Observational data: associations, not effects.

Original publication

Prevalence of Subclinical Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. Published 22 November 2023. doi:10.1016/j.jchf.2023.09.023

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