Arrhythmias & electrophysiology
Prognosis and Management of Recurrent Stenosis After Pulmonary Vein Stenting: A Prospective Study
Main finding · Recurrent ISR (per vein)Result — go to the resultHazard ratio 0.21 95% CI 0.07–0.64Authors' conclusion
Our modified stent-in-stent implantation approach is superior to BA for treating pulmonary vein ISR, by reducing recurrent restenosis rate and improving exercise endurance.
Study context
- Population
- Patients with severe pulmonary vein stenosis after radiofrequency ablation for AF, treated with stenting174 stented veins
- Participants
- 107 patients
- Exposure
- Modified stent-in-stent vs balloon angioplasty for pulmonary vein in-stent restenosis (ISR)
- Outcome
- Recurrent ISR after reintervention
Main finding
Recurrent ISR (per vein)
Hazard ratio
0.21
95% CI 0.07–0.64
P = 0.02
Events by group
Stent-in-stentvs BA
HR 0.21 (95% CI 0.07–0.64); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
Reintervention success rate
ISR after initial stenting (single group)
- Veins with ISR (43 of 174; 36 patients)
- 24.7%
Stent diameter, veins with vs without ISR
- Smaller stents in veins developing ISR: 7.8 ± 0.8 mm vs 9.2 ± 0.7 mm
- P = 0.008
Exercise endurance and WHO cardiac functional class · 6 and 12 months
- Greater exercise endurance with stent-in-stent vs balloon angioplasty (BA) (F = 7.2)
- P < 0.05
- Better WHO functional class with stent-in-stent vs BA (F = 4.4)
- P < 0.05
Original publication
Prognosis and Management of Recurrent Stenosis After Pulmonary Vein Stenting: A Prospective Study. JACC Clin Electrophysiol. Published 27 November 2024. doi:10.
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