Arrhythmias & electrophysiology
Pulsed Field Ablation as First-Line Therapy for Atrial Fibrillation: A Substudy of the EU-PORIA Registry
Authors' conclusion
In this large real-world PFA registry, freedom from AF/atrial tachycardia recurrence after 1 year was similar in patients undergoing PFA as a first-line treatment and those with prior failed AAD therapy.
Study context
- Population
- Patients with atrial fibrillation (AF) treated with the pentaspline pulsed field ablation (PFA) catheter; excluding incomplete AAD history, long-standing persistent AF and repeat ablationof 1233 enrolled
- Participants
- 1,091 patients
- Comparison
- First-line PFA vs PFA after failed class I/III AAD
- First-line PFAn = 589
- Prior AADn = 502reference
- Primary endpoint
- Freedom from AF/atrial tachycardia recurrence (episode >30 s)
- Follow-up
- 1 year
Methodological detailsall-comer registry, consecutive patients, 7 high-volume European centres, Treated and followed per institutional standard of care
- All-comer registry
- Consecutive patients
- 7 high-volume European centres
- Treated and followed per institutional standard of care
Primary result
As reported in the abstract
Freedom from AF/atrial tachycardia recurrence
P = 0.076
Further findings
Paroxysmal AF (baseline)
P < 0.001
Pulmonary vein isolation-only
P < 0.001
Original publication
Pulsed Field Ablation as First-Line Therapy for Atrial Fibrillation: A Substudy of the EU-PORIA Registry. Circ Arrhythm Electrophysiol. Published 27 November 2024. doi:10.
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