Valvular & structural heart disease
Prognostic impact of biplane vena contracta width in patients with atrial functional mitral regurgitation
Primary result · Composite of all-cause mortality, heart failure hospitalization, and mitral valve interventionsResult — go to the resultAdjusted hazard ratio 2.97 95% CI 2.04–4.32Authors' conclusion
The Bi-VCW was independently associated with poorer outcomes in patients with AFMR and demonstrated superiority over the guideline-recommended parameters. It could serve as an independent and first surrogate for risk stratification in patients with AFMR.
Study context
- Population
- Patients with moderate or severe atrial functional mitral regurgitation (atrial functional MR (AFMR))
- Participants
- 423 studied patients
- Comparison
- Bi-VCW vs PLAX-VCW and effective regurgitant orifice area (EROA) for discrimination of the primary outcome
- Primary endpoint
- Composite of:
- All-cause mortality
- Heart failure hospitalization
- Mitral valve interventions
Primary result
As reported in the abstract
Composite of:
- All-cause mortality
- Heart failure hospitalization
- Mitral valve interventions
Adjusted hazard ratio
2.97
95% CI 2.04–4.32
P < 0.001
Bi-VCW vs PLAX-VCW and EROA for discrimination of the primary outcome
adjusted hazard ratio 2.97 (95% CI 2.04–4.32); P < 0.001
- Bi-VCW area under the time-dependent receiver operating characteristic curve (highest vs PLAX-VCW and EROA)
- 0.76
- Bi-VCW optimal threshold
- 7.9 mm
- Sensitivity
- 76%
- Specificity
- 65%
Further findings
Bi-VCW vs PLAX-VCW · Bi-VCW higher
P < 0.001
Severe mitral regurgitation (MR) by Bi-VCW >8.0 mm
- Stratified as severe MR
- 48%
Original publication
Prognostic impact of biplane vena contracta width in patients with atrial functional mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 22 June 2026. doi:10.
Summarised from the published abstract; every number is checked against it