Heart failure & cardiomyopathies
Prognostic Impact of MitraScore in Elderly Asian Patients with Heart Failure: Sub-Analysis of FRAGILE-HF
Primary result · All-cause deathResult — go to the resultAdjusted hazard ratio 1.22 95% CI 1.10–1.36Authors' conclusion
MitraScore developed for patients undergoing TEER also showed strong discriminative power in HF patients.
Study context
- Population
- Elderly patients (>65 years) hospitalized for heart failure (HF)
- Participants
- 1,100 patients
- Comparison
- MitraScore risk groups; MitraScore vs other simple HF risk scores
- Low-riskn = 326
- Moderate-riskn = 571
- High-riskn = 203
- Primary endpoint
- All-cause death
- Follow-up
- 2 years
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Adjusted hazard ratio
1.22
95% CI 1.10–1.36
P < 0.001
MitraScore
adjusted HR 1.22 (95% CI 1.10–1.36); P < 0.001
- All-cause deaths observed
- 226
- MitraScore stratified patients in Kaplan-Meier analysis
- P < 0.001
- Continuous net reclassification improvement (NRI) vs GWTG-HF, BIOSTAT compact, AHEAD, AHEAD-U, HANBAH
- 0.20, 0.22, 0.39, 0.39, and 0.29
Secondary outcomes
Composite of all-cause death and HF rehospitalization · 2 years
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| MitraScore | 1.17 (1.09–1.26) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
CV death · 2 years
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| MitraScore | 1.24 (1.10–1.39) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
- Composite of all-cause death and HF rehospitalization — Composite endpoints observed
- 478
- CV death — CV deaths observed
- 183
- CV death — Continuous NRI vs GWTG-HF, BIOSTAT compact, AHEAD, AHEAD-U, HANBAH
- 0.20, 0.22, 0.42, 0.40, and 0.29
- CV death: NRI all P-values < 0.02
Original publication
Prognostic Impact of MitraScore in Elderly Asian Patients with Heart Failure: Sub-Analysis of FRAGILE-HF. ESC Heart Fail. Published 19 January 2024. doi:10.
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