Heart failure & cardiomyopathies
An Altered Plasma Lipidome–Phenome Network Characterizes Heart Failure with Preserved Ejection Fraction
Authors' conclusion
We did not find significant direct associations between plasma lipidomic parameters and HFpEF and therefore could not conclude that any specific lipids are biomarkers of HFpEF.
Study context
- Population
- Heart failure with preserved ejection fraction (HFpEF) patients and control subjects; 8 women, 22 men, mean age 67.8 ± 8.6 SD
- Participants
- 18 vs 12
- Comparison
- HFpEF vs controls
- HFpEFn = 18
- Controlsn = 12reference
- Outcome
- Association of plasma lipid profiles or lipid entities with clinical and functional echocardiographic parameters in HFpEF
Methodological detailsmass spectrometry-based shotgun lipidomics, exploratory network analysis
- Mass spectrometry-based shotgun lipidomics
- Exploratory network analysis
Main finding
As reported in the abstract
Plasma lipid profiles, HFpEF vs controls
- No significant differences in lipid profiles between HFpEF and controls (lipids binned by carbon chain length or double bonds, or individual lipid species)
Observational data: associations, not effects.
Further findings
Lipids vs smoking status and hyperlipidaemia
- Striking correlation of selected lipids with smoking status, independent of disease status, and of specific lipids with hyperlipidaemia
- False discovery rate (FDR) <0.1 or FDR < 0.01
Lipid–phenome correlation network (exploratory)
- HFpEF: significantly stronger correlations of cholesterol ester and phosphatidylcholine (PC) species with left atrial volume index, LV end-diastolic diameters and heart rate
- FDR < 0.1
- Controls: significantly stronger negative correlations of PC and sphingomyelin species with LV mass index or SBP
- FDR < 0.1
- Exploratory network analysis
Clinical and echocardiographic parameters, HFpEF vs controls
- More fatigue in HFpEF
- P < 0.001
- More often CAD in HFpEF
- P = 0.04
- More medications (beta-blockers) in HFpEF
- P < 0.001
- N-terminal pro-brain natriuretic peptide (NT-proBNP) different
- P < 0.001
- LV mass index different
- P = 0.005
- Left atrial volume index different
- P = 0.001
- LV filling index different
- P < 0.001
- Lower LV end-diastolic diameter in HFpEF
- P = 0.014
- No difference in LVEF
- No significant difference in age, BMI, SBP, DBP, waist-to-hip ratio
Original publication
An Altered Plasma Lipidome–Phenome Network Characterizes Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 19 January 2024. doi:10.
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