Prognostic Role of High-Sensitivity Cardiac Troponin T in Patients with Cardiac Sarcoidosis: Insights from ILLUMINATE-CS
Authors' conclusion
In patients with CS, a high hs-cTnT level is a useful predictor of adverse events, and combined measurement of hs-cTnT and BNP further improves the prognostic value.
Study context
- Population
- Patients diagnosed with cardiac sarcoidosis with high-sensitivity cardiac troponin T (hs-cTnT) measured at diagnosis (62.2 ± 10.9 years, 31.1% male)24 primary outcomes
- Participants
- 103 patients
- Comparison
- High vs low hs-cTnT level at diagnosis
- Primary endpoint
- All-cause death, fatal ventricular arrhythmia events and HF hospitalisation
- Follow-up
- Median 2.6 (IQR 1.6-5.7) years
Primary result
As reported in the abstract
Hazard ratio (95% CI)P value
Log-transformed hs-cTnT
4.368(1.032–18.480)
P = 0.045Log-transformed BNP
3.127(1.029–9.499)
P = 0.044Further findings
| Outcome | Fold increased risk (95% CI) |
|---|---|
| Primary outcome, combined high hs-cTnT and high BNP (>140 pg/mL) vs both low | 3.49 (1.23–9.88) |
Original publication
Prognostic Role of High-Sensitivity Cardiac Troponin T in Patients with Cardiac Sarcoidosis: Insights from ILLUMINATE-CS. ESC Heart Fail. Published 27 December 2024. doi:10.
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