Heart failure & cardiomyopathies
Prognostic significance of remotely monitored nocturnal heart rate in heart failure patients with reduced ejection fraction
Authors' conclusion
In remotely monitored patients with implantable cardioverter-defibrillator/CRT-D on β-blocker therapy for heart failure, elevated heart rates (nHR >65 beats/min and 24h-HR >75 beats/min) were associated with increased mortality and VT/VF risk. nHR showed a stronger association than 24h-HR with worst prognosis and lowest physical activity.
Study context
- Population
- Chronic HF patients on β-blocker therapy with ICD or CRT-D under continuous remote monitoring41% with CRT-D
- Participants
- 1,330 patients
- Exposure
- Highest vs lowest quartile of remotely monitored nocturnal HR (nocturnal heart rate (nHR)) and 24-h mean HR (24h-HR)
- Outcome
- Nonarrhythmic death and device-treated VT/VF
- Follow-up
- Median 25 months
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
Highest nHR quartilevs Lowest nHR quartilenonarrhythmic death
2.25(1.13–4.50)
P = 0.021Highest nHR quartilevs Lowest nHR quartileVT/VF
1.98(1.40–2.79)
P < 0.001Highest 24h-HR quartilevs Lowest 24h-HR quartileVT/VF
2.13(1.52–2.99)
P < 0.001Highest 24h-HR quartilevs Lowest 24h-HR quartilenonarrhythmic mortality
1.80(1.00–3.22)
P = 0.05Observational data: associations, not effects.
Further findings
- Highest nHR quartile had the lowest physical activity vs every other nHR quartile
- P ≤ 0.0004
Original publication
Prognostic significance of remotely monitored nocturnal heart rate in heart failure patients with reduced ejection fraction. Heart Rhythm. Published 28 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →