Prognostic Utility of Quantitative Perfusion Positron Emission Tomography (PET) in Patients With Prior CABG: Incremental Value of Myocardial Flow Reserve and Coronary Vascular Resistance
Authors' conclusion
PET-derived MFR and CVR provide independent and incremental prognostic value in coronary artery bypass grafting patients, enhancing risk stratification beyond conventional perfusion and function parameters.
Study context
- Population
- Patients with prior CABG undergoing Rubidium-82 PET myocardial perfusion imaging, May 2017–November 2023
- Participants
- 556 patients
- Exposure
- Impaired vs preserved PET-derived myocardial flow reserve (MFR) and coronary vascular resistance (CVR)
- Outcome
- MACE:
- Cardiac mortality
- Nonfatal MI
- Follow-up
- Median 676 (482-1077) days
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
MACE
Adjusted hazard ratio (95% CI)P value
MFR ≤2.05
2.954(1.287–6.780)
P = 0.011CVR ≥66.4 mm Hg·min·g/mL
2.356(1.075–5.161)
P = 0.032MFR and CVR combined
5.437(2.700–10.950)
P < 0.001- Patients with major adverse cardiovascular events (MACE)
- 39 (7.0%)
- Impaired MFR and CVR each associated with increased MACE rates
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Expanded MACE (MACE plus hospitalization for unstable angina or HF)
- Patients with expanded MACE
- 74 (13.3%)
- Impaired MFR and CVR each associated with increased expanded MACE rates
- P < 0.001
Event rates by combined MFR and CVR status
- Significant differences across groups
- P < 0.001
Original publication
Prognostic Utility of Quantitative Perfusion PET in Patients With Prior CABG: Incremental Value of Myocardial Flow Reserve and Coronary Vascular Resistance. Circ Cardiovasc Imaging. Published 27 October 2025. doi:10.
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