Prognostic value of global myocardial flow reserve in patients with history of coronary artery bypass grafting
Main findingResult — go to the resultHazard ratio 2.06 95% CI 1.23–3.44Authors' conclusion
Among patients with a history of CABG, PET-derived global MFR <2 may identify those with a high risk of subsequent cardiovascular events, especially heart failure, independent of cardiovascular risk factors and perfusion data.
Study context
- Population
- Patients with prior coronary artery bypass grafting (CABG) and a clinical indication for positron emission tomography (PET), Houston Methodist DeBakey Heart and Vascular Center PET registry66% with myocardial flow reserve (MFR) <2
- Participants
- 836 patients
- Exposure
- Impaired MFR vs preserved MFR
- Outcome
- Composite of:
- All-cause death
- MI/unplanned revascularization
- HF admissions
- Follow-up
- Median 12 (IQR 4-24) months
Methodological detailsregistry, single-centre
- Registry
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
2.06
95% CI 1.23–3.44
MFR <2vs MFR ≥2
HR 2.06 (95% CI 1.23–3.44)
- Incident events, total
- 122
Observational data: associations, not effects.
Further findings
HF admissions
- Impaired MFR associated with higher risk of HF admissions (adjusted; 95% CI 1.11-7.67)
- HR 2.92
- Adjusted analysis
All-cause death
- Impaired MFR not significantly associated with all-cause death (adjusted; 95% CI 0.85-4.79)
- HR 2.01
- Adjusted analysis
Myocardial infarction (MI)/unplanned revascularization
- Impaired MFR not significantly associated with MI/UR (adjusted; 95% CI 0.92-4.05)
- HR 1.93
- Adjusted analysis
Original publication
Prognostic value of global myocardial flow reserve in patients with history of coronary artery bypass grafting. Eur Heart J Cardiovasc Imaging. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →