The prognostic value of global longitudinal strain in patients with myocardial infarction and preserved ejection fraction: a prespecified substudy of the REDUCE-AMI trial
Authors' conclusion
In patients after AMI with preserved LVEF, GLS did not add prognostic value regarding death from any cause or new AMI. In addition, beta-blocker treatment did not alter the prognostic information obtained from GLS. Consequently, this study does not support an additive value of GLS compared with standard echocardiographic measurement in this patient population.
Study context
- Population
- Patients after acute myocardial infarction (AMI) with preserved left ventricular ejection fraction (LVEF)28.6% of the total population, 324 (22.6%) excluded from global longitudinal strain (GLS) analysis due to poor image quality or incompatible equipment
- Participants
- 1,436 patients
- Comparison
- GLS vs LVEF as prognostic methods
Primary result
As reported in the abstract
GLS
Median GLS
17.3%
Further findings
Prognostic value of GLS compared with LVEF for death from any cause or new AMI
- Likelihood ratio test: no difference
- P = 0.56
- Results robust when adding beta-blocker randomization status as an independent variable
- Models adjusted for age, sex, hypertension, smoking, diabetes, previous AMI, and multi-vessel disease
Original publication
The prognostic value of global longitudinal strain in patients with myocardial infarction and preserved ejection fraction: a prespecified substudy of the REDUCE-AMI trial. Eur Heart J Cardiovasc Imaging. Published 15 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →