Hypertensive Disorders of Pregnancy in Patients With Cardiac Disease: Risk and Impact on Delivery Timing
Authors' conclusion
Odds of HDP and delivering at an earlier gestational age differs across CVD subtypes, notably higher in those with pulmonary HTN and cardiomyopathy
Study context
- Population
- Obstetric patients >18 years delivering between October 1, 2015, and December 31, 202020,021 with cardiovascular disease (CVD)
- Participants
- 4,606,247 patients
- Exposure
- CVD subtypes vs no CVD
- Outcome
- Odds of hypertensive disorders of pregnancy (gestational HTN or pre-eclampsia)
Methodological detailsPremier Healthcare Database, multivariable mixed effects regression
- Premier Healthcare Database
- Multivariable mixed effects regression
Main finding
As reported in the abstract
HDP by CVD subtype
Each group vs no CVDAdjusted odds ratio (95% CI)
Congenitallowest risk
0.9(0.8–1.0)
Pulmonary HTNhighest risk
1.5(1.3–1.8)
Cardiomyopathyhighest risk
1.5(1.4–1.6)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | CVD | No CVDweeks |
|---|---|---|
| Gestational age at delivery, without HDPCVD value is the range across subtypes | 36.4-38.0 weeks | 38.4 |
| Gestational age at delivery, severe pre-eclampsia | 33.1-34.6 weeks | 35.5 |
Gestational age at delivery, without hypertensive disorders of pregnancy (HDP)
- Patients with CVD delivered earlier than those without CVD
Gestational age at delivery, severe pre-eclampsia
- Patients with CVD delivered earlier than those without CVD
Original publication
Hypertensive Disorders of Pregnancy in Patients With Cardiac Disease: Risk and Impact on Delivery Timing. JACC Adv. Published 15 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →