Risk-guided disease management to prevent heart failure in adult cancer survivors of previous cardiotoxic cancer treatments: Baseline results of the REDEEM trial
Study context
- Population
- Adult cancer survivors ≥40 years old, ≥5 years post potentially-cardiotoxic therapy, with ≥1 heart failure (HF) risk factorsurvivors screened, 604 underwent echocardiography, 145 (24%) had subclinical/stage B heart failure (SBHF)
- Participants
- 1,124 survivors
- Planned comparison
- Multidisciplinary cardio-oncology disease management plan or usual care
- Primary endpoint
- change in cardiorespiratory fitness (VO2peak)
- Follow-up
- Over 6 months
Methodological detailsrandomized, baseline results, echocardiographic screening for SBHF
- Randomized
- Baseline results
- Echocardiographic screening for SBHF
No results yet. This paper sets out the design of a trial; its results are to come.
Baseline
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Association between abnormal GLS and functional impairment · baselineAbnormal GLSvs functional impairmentNot significantly associated | 0.90 (0.72–1.11) | P = 0.360 | |
| 0.512Odds ratio (log scale) |
SBHF prevalence among those undergoing echocardiography (baseline)
- Had SBHF (of 604 who underwent echocardiography)
- 145 (24%)
- Age of those with SBHF
- 68±18 years
- Women among those with SBHF
- 81%
Cancer type among those eligible for randomization · baseline
- Breast cancer
- 64%
- Hematological malignancy
- 35%
Baseline cardiac function and functional capacity
- 3D-LVEF
- 52.8 ± 6.8%
- GLS
- 15.6 ± 2.1%
- Functional impairment (VO2peak≤18ml/kg/min-1)
- 39%
Correlates of abnormal GLS and functional impairment · baseline
- Abnormal GLS associated with age, BMI, diabetes and anthracycline exposure
- Functional impairment only associated with age
Original publication
Risk-guided disease management to prevent heart failure in adult cancer survivors of previous cardiotoxic cancer treatments: Baseline results of the REDEEM trial. Am Heart J. Published 16 September 2025. doi:10.
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