Prognostic value of growth differentiation factor-15 3 months after an acute chest pain admission
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 2.2 95% CI 1.4–3.3Authors' conclusion
High GDF-15 concentrations 3 months after admission for suspected NSTE-ACS are associated with long-term mortality and cardiovascular events, independent of traditional risk factors and troponin T. A change in GDF-15 concentration can provide prognostic information.
Study context
- Population
- Patients admitted with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), GDF-15 measured at baseline and 3 months
- Participants
- 758 patients
- Exposure
- GDF-15 ≥1200 pg/mL vs <1200 pg/mL at 3 months
- GDF-15 ≥1200 pg/mLn = 248
- GDF-15 <1200 pg/mLn = 510reference
- Outcome
- All-cause mortality
- Follow-up
- Median 1540 (IQR 1087-1776) days after the 3-month visit
Main finding
As reported in the abstract
Adjusted hazard ratio
2.2
95% CI 1.4–3.3
P < 0.001
By group
GDF-15 ≥1200 pg/mL vs <1200 pg/mL at 3 months
adjusted HR 2.2 (95% CI 1.4–3.3); P < 0.001
Observational data: associations, not effects.
Further findings
Composite of all-cause mortality, incident MI and HF hospitalisation
| Comparison | GDF-15 ≥1200 pg/mL | GDF-15 <1200 pg/mL | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| GDF-15 at 3 months (log2 transformed) | 25% | 4% | 1.9 (1.4–2.7) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality per 10% change in GDF-15 from baseline to 3 monthsAdjusted for baseline GDF-15 | 1.06 (1.01–1.13) | P = 0.031 | |
| 0.512Hazard ratio (log scale) |
- Composite of all-cause mortality, incident MI and HF hospitalisation: independent of traditional risk factors and baseline troponin T
Original publication
Prognostic value of growth differentiation factor-15 3 months after an acute chest pain admission. Heart. Published 24 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it