Valvular & structural heart disease
Prognostic value of left ventricular global longitudinal strain in transcatheter edge-to-edge repair for chronic primary mitral regurgitation
Main finding · All-cause mortality or HF hospitalisation (worst LVGLS quartile, with LV dysfunction/dilatation)Result — go to the resultHazard ratio 1.68 95% CI 1.02–5.46Authors' conclusion
TEER for chronic primary MR is feasible, safe, and efficacious irrespective of baseline LVGLS. Yet, worse baseline LVGLS forecasts a less favourable post-procedural course, presumably reflecting a higher-risk patient profile.
Study context
- Population
- Patients undergoing isolated, first-time transcatheter edge-to-edge repair (TEER) for chronic primary mitral regurgitation (MR)
- Participants
- 323 patients
- Exposure
- Baseline left ventricular global longitudinal strain (LVGLS) quartiles
- Outcome
- All-cause mortality or HF hospitalisation
- Follow-up
- First year after intervention
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
All-cause mortality or HF hospitalisation (worst LVGLS quartile, with LV dysfunction/dilatation)
Hazard ratio
1.68
95% CI 1.02–5.46
P = 0.047
>−12%
HR 1.68 (95% CI 1.02–5.46); P = 0.047
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality (worst LVGLS quartile)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| >−12% · 16.9% vs. 6.3%, Log-Rank P = 0.005 | 1.75 (1.08–4.74) | P = 0.041 | |
| 0.20.5125Hazard ratio (log scale) |
Mitral reinterventions, significant residual MR and/or functional disability
- No association between baseline LVGLS and other endpoints
1-month post-procedural LVGLS (exploratory)
- Worse than baseline LVGLS by
- 1.6%
- More impaired 1-month value (not deterioration) conferred heightened risk for primary outcome
- Exploratory analysis
Original publication
Prognostic value of left ventricular global longitudinal strain in transcatheter edge-to-edge repair for chronic primary mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 26 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it