Valvular & structural heart disease
Prognostic Value of Longitudinal Strain Relative Apical Sparing in Severe Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement (TAVR)
Main finding · 2-year CV mortalityResult — go to the resultHazard ratio 2.01 95% CI 1.22–3.29Authors' conclusion
RASP, particularly when combined with hypoalbuminemia and low BMI, identifies a high-risk phenotype associated with adverse outcomes after TAVR.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing TAVR (mean age 81.7 ± 5.7 years, 48.8% male)Relative apical sparing pattern (RASP) in 19.2%
- Participants
- 598 patients
- Exposure
- RASP vs no RASP
- Outcome
- CV mortality
- Follow-up
- 2 years
Main finding
2-year CV mortality
Hazard ratio
2.01
95% CI 1.22–3.29
P = 0.006
RASPvs No RASP
HR 2.01 (95% CI 1.22–3.29); P = 0.006
As reported in the abstract
Observational data: associations, not effects.
Further findings
Other independent predictors of 2-year cardiovascular (CV) mortality
| HR (95% CI) | P value | ||
|---|---|---|---|
| Low serum albumin (<4.0 g/dL) | 2.40 (1.50–3.84) | P < 0.001 | |
| Low BMI (≤25.5 kg/m²) | 1.71 (1.07–2.73) | P = 0.025 | |
| 0.20.5125Hazard ratio (log scale) |
2-year CV mortality by composite risk score (RASP, low albumin, low BMI; 0-3 points)
| Score 0 | Score 1 | Score 2 | Score 3 | HR (95% CI) | P value | ||
|---|---|---|---|---|---|---|---|
| Score ≥2Adjusted | 6.3% | 11.4% | 27.2% | 35.3% | 3.42 (2.14–5.48) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
- 2-year CV mortality by composite risk score (RASP, low albumin, low BMI; 0-3 points): log-rank P < 0.001
Original publication
Prognostic Value of Longitudinal Strain Relative Apical Sparing in Severe Aortic Stenosis Patients Undergoing TAVR. ESC Heart Fail. Published 27 July 2025. doi:10.
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