Valvular & structural heart disease
Prevalence and significance of relative apical sparing in aortic stenosis: insights from an echo and cardiovascular magnetic resonance study of patients referred for surgical aortic valve replacement
Authors' conclusion
RASP is not specific of cardiac amyloidosis. It may also be found in severe symptomatic AS without amyloidosis, reflecting advanced LV disease, being mostly reversible after surgery.
Study context
- Population
- Severe symptomatic aortic stenosis (AS) referred for surgical aortic valve replacement (AVR)119 underwent AVR
- Participants
- 150 participants
- Exposure
- Patients with relative apical sparing pattern (RASP) vs without RASP
- RASPn = 23
- Outcome
- Prevalence of RASP
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
RASP prevalence
RASP
15.3%
23
Observational data: associations, not effects.
Further findings
NT-proBNP, RASP vs no RASP · pre-operative
- Higher NT-proBNP with RASP: 1564 (766-3318) vs 548 (221-1440) pg/mL
- P = 0.010
LVEF, RASP vs no RASP · pre-operative
- Lower LVEF with RASP: 53.7 ± 10.5 vs 60.5 ± 10.2%
- P = 0.005
Absolute late gadolinium enhancement (LGE) mass at cardiac magnetic resonance (CMR), RASP vs no RASP · pre-operative
- Higher LGE mass with RASP: 9.7 (5.4-14.1) vs 4.8 (1.9-8.6) g
- P = 0.016
LV mass and septal wall thickness, RASP vs no RASP · pre-operative
- Significantly higher LV mass and increased septal wall thickness with RASP
RASP persistence after AVR · 3-6 months after AVR
- RASP disappeared in all except two patients
- 2
Original publication
Prevalence and significance of relative apical sparing in aortic stenosis: insights from an echo and cardiovascular magnetic resonance study of patients referred for surgical aortic valve replacement. Eur Heart J Cardiovasc Imaging. Published 26 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →