Valvular & structural heart disease
Prognostic value of mitral valve haemodynamic parameters obtained by intraprocedural echocardiography in transcatheter edge-to-edge repair
Authors' conclusion
Immediate post-TEER MR severity and the relative change in TMPG are predictive of clinical and echocardiographic outcomes following the procedure.
Study context
- Population
- Consecutive patients undergoing isolated mitral transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR), 2013–2020 (no prior mitral procedures, clip deployed)481 (52%) functional MR
- Participants
- 926 patients
- Exposure
- Intraprocedural transesophageal echocardiographic (TEE) haemodynamic parameters as predictors of outcome after mitral TEER
- Outcome
- All-cause mortality or HF hospitalization
- Follow-up
- 458 (IQR, 104-1035) days
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
All-cause mortality or HF hospitalization — independent intraprocedural predictors after clip deployment (multivariable analysis) · whole study period
Hazard ratio (95% CI)P value
An above mild MR
1.49(1.05–2.13)
P = 0.026A 100% or more increase from baseline in the transmitral mean pressure gradient (TMPG)
1.32(1.01–1.72)
P = 0.039Observational data: associations, not effects.
Secondary outcomes
Heart failure (HF) hospitalizations and greater-than-mild 1-month MR
- Post-clip MR above mild and absence of bilateral normal pulmonary venous flow pattern (PVFP) associated with increased risk
Original publication
Prognostic value of mitral valve haemodynamic parameters obtained by intraprocedural echocardiography in transcatheter edge-to-edge repair. Eur Heart J Cardiovasc Imaging. Published 7 February 2023. doi:10.
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