Valvular & structural heart disease
Prognostic Value of the Right Ventricular-to-Left Ventricular Volume Ratio in Tricuspid Regurgitation
Authors' conclusion
The RV/LVvol ratio is a strong predictor of mortality in advanced TR, capturing ventricular remodeling not identified by conventional metrics.
Study context
- Population
- Patients with ≥moderate tricuspid regurgitation (TR) who underwent cardiac magnetic resonance imaging between 2005 and 2024patients with ≥moderate TR
- Participants
- 949 patients
- Exposure
- The right ventricular (RV)/LVvol ratio was assessed as a dichotomous variable (normal: <1.27, abnormal: ≥1.27) and by severity strata
- Outcome
- Abnormal RV/LVvol ratio
Main finding
As reported in the abstract
Of the 949 patients, abnormal RV/LVvol ratio
43.6%
Among 528 patients with a normal RV end-diastolic volume index, abnormal RV/LVvol ratio
178
33.7%
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · mean follow-up of 4.8 ± 4.5 yearsAbnormal RV/LVvol ratiovs normal RV/LVvol ratioAdjusting for covariates | 1.47 (1.01–2.14) | P = 0.043 | |
| All-cause mortality · mean follow-up of 4.8 ± 4.5 yearsSevere RV/LVvol ratiovs normal RV/LVvol ratioSevere ratios conferring the highest risk · adjusting for covariates | 2.20 (1.31–4.76) | P = 0.045 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- All-cause mortality — patients died
- 236
Incremental prognostic value (global chi-square)
- Age/sex
- 24.7
- With RV ejection fraction
- 47.1
- With RV end-diastolic volume index
- 59.3
- With the addition of RV/LVvol ratio
- 68.3
- P = 0.005
Original publication
Prognostic Value of the Right Ventricular-to-Left Ventricular Volume Ratio in Tricuspid Regurgitation. JACC Adv. Published 4 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →