Arrhythmias & electrophysiology
Prognostically Optimal Heart Rate at Discharge in Hospitalized Patients With Heart Failure and Atrial Fibrillation
Main finding · Composite of all-cause death and HF rehospitalizationResult — go to the resultHazard ratio 1.79 95% CI 1.04–3.07Authors' conclusion
The findings suggest that controlling HR to less than 80 beats/min at discharge may lead to better clinical outcomes in patients with HF and persistent AF.
Study context
- Population
- Patients hospitalised with heart failure (HF) and persistent atrial fibrillation (AF) (excluding sinus rhythm, paroxysmal AF, pacemakers or unrecorded discharge HR)from 1,930 HF hospitalizations
- Participants
- 334 patients
- Exposure
- Discharge HR >81 beats/min vs HR <60 beats/min
- Outcome
- Composite of:
- All-cause death
- HF rehospitalization
- Follow-up
- Median 389 days
Methodological detailsconsecutive HF hospitalizations database
- Consecutive HF hospitalizations database
Main finding
As reported in the abstract
Hazard ratio
1.79
95% CI 1.04–3.07
HR >81 beats/minvs HR <60 beats/min
HR 1.79 (95% CI 1.04–3.07)
- Patients reaching the primary endpoint (overall)
- 133 (39.8%)
- Significantly higher primary endpoint incidence with HR >81 vs <60 beats/min (Kaplan-Meier, log-rank test for trend)
- P = 0.039
Observational data: associations, not effects.
Original publication
Prognostically Optimal Heart Rate at Discharge in Hospitalized Patients With Heart Failure and Atrial Fibrillation. JACC Adv. Published 24 July 2024. doi:10.
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