Valvular & structural heart disease
Prospective study on the impact of different antithrombotic therapies on subclinical leaflet thickening and its temporal dynamics in transcatheter aortic valves—The NOTION-4 trial
Study context
- Population
- Transcatheter aortic valve replacement (TAVR) patients with no indication for oral anticoagulant (OAC) therapyplanned enrolment
- Participants
- 324 patients
- Planned comparison
- Early 3-month direct oral anticoagulant (DOAC) then SAPT vs lifelong SAPT after TAVR
- Primary endpoint
- Number of patients with ≥1 bioprosthetic aortic valve leaflet with HALT on cardiac 4DCT
- Follow-up
- 1 year
Methodological detailsdesign paper, superiority, Enrolment started 2021; last patient expected by end of 2024, HALT and clinical endpoints evaluated at 3 months, 1 year and 5 years
- Design paper
- Superiority
- Enrolment started 2021; last patient expected by end of 2024
- HALT and clinical endpoints evaluated at 3 months, 1 year and 5 years
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Prospective study on the impact of different antithrombotic therapies on subclinical leaflet thickening and its temporal dynamics in transcatheter aortic valves—The NOTION-4 trial. Am Heart J. Published 5 October 2024. doi:10.
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