Arrhythmias & electrophysiology
Prospective Observational Study on the Accuracy of Predictors of Permanent Pacemaker Secondary to High-Grade Atrioventricular Conduction Block After Transcatheter Aortic Valve Implantation (TAVI) (CONDUCT-TAVI)
Authors' conclusion
The incidence of conduction abnormalities remains high after TAVI, and after factoring in anatomic, procedural, and electrophysiological factors, a baseline right bundle branch block and electrophysiology study-derived measures of atrioventricular conduction were the most significant predictors of PPMI.
Study context
- Population
- Patients undergoing TAVI
- Participants
- 200 patients
- Outcome
- PPMI secondary to high-grade atrioventricular block
- Follow-up
- 1 year
Methodological details2 centres, implantable loop recorders for 1 year
- 2 centres
- Implantable loop recorders for 1 year
Main finding
As reported in the abstract
PPMI due to high-grade atrioventricular block
- Permanent pacemaker implantation (PPMI) due to high-grade AV block
- 21.0%
- Early PPMI
- 13.5%
- Late PPMI
- 7.5%
- Preexisting RBBB, adjusted OR
- 5.45 (95% CI 1.67-17.84; P=0.005)
- ΔHV interval >10 ms, adjusted OR
- 3.62 (95% CI 1.23-10.67; P=0.020)
- Pre-TAVI rapid atrial pacing-induced AV Wenckebach, adjusted OR
- 3.70 (95% CI 1.37-9.98; P=0.010)
Observational data: associations, not effects.
Secondary outcomes
CONDUCT-TAVI score
- AUC
- 0.794
- NPV
- 98%
New-onset persistent LBBB (>24 hours)
- New-onset persistent LBBB
- 19.1%
New-onset AF · 1 year
- New-onset AF
- 21.7%
Original publication
Prospective Observational Study on the Accuracy of Predictors of Permanent Pacemaker Secondary to High-Grade Atrioventricular Conduction Block After TAVI (CONDUCT-TAVI). Circ Cardiovasc Interv. Published 15 September 2025. doi:10.
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