Valvular & structural heart disease
Prospective Quantification of Tricuspid Regurgitation With Echocardiography vs 4D Flow Cardiac Magnetic Resonance
Authors' conclusion
Grading of TR was frequently discordant between TTE and 4D magnetic resonance imaging. Further studies are needed to elucidate the clinical impact of concordant/discordant TR grading on multimodality imaging.
Study context
- Population
- Patients with ≥ moderate tricuspid regurgitation (TR) on TTE, excluding other severe valvulopathy, end-stage renal disease, or pacemakerspatients enrolled (mean age 78.5 ± 7.6 years, 53.8% men)
- Participants
- 52 patients
- Exposure
- TR grading with 4D-CMR and transthoracic echocardiography
- Outcome
- Agreement between TTE and CMR-derived TR volume
Main finding
As reported in the abstract
Kappa (fair agreement)
0.28, 95% CI: 0.13-0.45
Patients with ≥ severe TR on TTE meeting severe TR volume criterion on cardiac magnetic resonance (CMR) (TR volume ≥45 mL)
10 of 31 patients
32%
Observational data: associations, not effects.
Further findings
Agreement between TTE and CMR-derived TR fraction
- Kappa (no agreement)
- 0.04, 95% CI: 0.13-0.46
- Patients with ≥ severe TR on TTE meeting severe TR criterion on CMR (TR fraction ≥50%)
- 3 of 31 patients (13%)
- CI as printed (0.13-0.46) does not contain the point estimate 0.04; 3 of 31 printed as 13%
Interval between CMR and TTE
- Median interval
- 2 days (Q1-Q3: 1-37 days)
Original publication
Prospective Quantification of Tricuspid Regurgitation With Echocardiography vs 4D Flow Cardiac Magnetic Resonance. JACC Adv. Published 2 May 2025. doi:10.
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