Heart failure & cardiomyopathies
Proteins Associated with Rehospitalization, Mortality and Diuretic Resistance in Acutely Decompensated Heart Failure
Authors' conclusion
Several proteins with known associations with cardiometabolic disease were associated with poor outcomes or reduced diuretic response. They have known roles in inflammatory, metabolic and cardiac or kidney remodelling pathways and may point to novel pathways in ADHF that warrant investigation as potential prognostic tools and targets for intervention.
Study context
- Population
- Patients hospitalized for acute decompensated heart failure (ADHF) at Yale New Haven Hospital from 2015 to 2020patients enrolled, median age 65 years, 36% female
- Participants
- 401 patients
- Exposure
- Associations of 369 serum cardiometabolic proteins (per SD protein concentration) with heart failure (HF) rehospitalization, mortality and diuretic response
Main finding
As reported in the abstract
Six proteins (C1QTNF1, CTSD, FCN2, SERPINA12, TFRC and TNFRSF10C) associated with increased risk, HR per SD protein concentration
1.2 to 1.35
SDC1 associated with decreased risk, HR per SD protein concentration
0.77
Observational data: associations, not effects.
Further findings
Mortality
- Three proteins (CDH1, FABP6 and TNC) associated with mortality, HR per SD protein concentration
- 1.35 to 1.64
Diuretic response
- Three proteins (MMP7, PGLYRP1 and REN) associated with reduced diuretic response, % Estimate per SD protein concentration
- −12.2% to −18.6%
Correlation between protein associations with lower diuretic response and greater mortality risk
- Spearman r (95% confidence interval: −0.56, −0.69)
- −0.63
Original publication
Summarised from the published abstract; every number is checked against it