Arrhythmias & electrophysiology
Proteinuria is independently associated with heart failure events in patients with atrial fibrillation: the Fushimi atrial fibrillation (AF) registry
Main finding · HF events (cardiac death or HF hospitalization)Result — go to the resultAdjusted hazard ratio 1.40 95% CI 1.13–1.74Authors' conclusion
Our community-based large prospective cohort suggests that proteinuria is independently associated with the incidence of HF events in Japanese patients with AF.
Study context
- Population
- Japanese patients with AF in the Fushimi AF Registry with available proteinuria dataof 4489 in registry
- Participants
- 2,164 patients
- Exposure
- Proteinuria vs no proteinuria
- Proteinurian = 606
- No proteinurian = 1,558reference
- Outcome
- HF events:
- Cardiac death
- HF hospitalization
- Follow-up
- Median 5.0 years
Methodological detailscommunity-based, registry
- Community-based
- Registry
Main finding
HF events:
Adjusted hazard ratio
1.40
95% CI 1.13–1.74
By group
Proteinuriavs No proteinuria
adjusted HR 1.40 (95% CI 1.13–1.74)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Unadjusted HR (95% CI) | |
|---|---|---|
| HF events, by age subgroupProteinuriavs No proteinuriaAge <75 years | 3.03 (2.12–4.34) | |
| HF events, by age subgroupProteinuriavs No proteinuriaAge ≥75 years | 1.59 (1.23–2.05) | |
| 0.20.5125Unadjusted hazard ratio (log scale) |
- Heart failure (HF) events, by age subgroup: interaction P < 0.01
HF events, by age subgroup
- Association consistent across other subgroups
Original publication
Proteinuria is independently associated with heart failure events in patients with atrial fibrillation: the Fushimi AF registry. Eur Heart J Qual Care Clin Outcomes. Published 5 January 2023. doi:10.
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