Arrhythmias & electrophysiology
Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease
Authors' conclusion
In IHD, PL-VT was associated with low LVEF and mortality. In DCM, PL-VT was not associated with mortality but a predictor of VT recurrence independent from LVEF.
Study context
- Population
- Consecutive ischemic heart disease (IHD) (2009–2016) or dilated cardiomyopathy (DCM) (2008–2018) patients undergoing ablation for monomorphic ventricular tachycardia (VT)86% men
- Participants
- 247 participants
- Exposure
- Pleomorphic VT (PL-VT) vs no PL-VT, in DCM and IHD
- DCMn = 95
- IHDn = 152reference
- Outcome
- VT recurrence and mortality
- Follow-up
- Median 30 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Independent predictors of VT recurrence in DCM
Hazard ratio (95% CI)
PL-VT
2.62(1.47–4.69)
Pathogenic mutation
2.13(1.16–3.91)
Anteroseptal VT substrate
1.75(1.00–3.07)
Observational data: associations, not effects.
Further findings
PL-VT prevalence
Events
| Outcome | IHD | DCM |
|---|---|---|
| Mortality · median follow-up 30 months | 48 | 31 |
| VT recurrence · median follow-up 30 months | 59 | 61 |
- PL-VT prevalence: P=0.003
- LVEF in IHD, PL-VT vs no PL-VT: PL-VT 28 (SD 9) %
- LVEF in IHD, PL-VT vs no PL-VT: No PL-VT 34 (SD 12) %
- LVEF in IHD, PL-VT vs no PL-VT: P=0.02
- Mortality: overall 79 (32%) died
- Mortality: P=0.88
- VT recurrence: overall 120 (49%)
- VT recurrence: P<0.001
LVEF in IHD, PL-VT vs no PL-VT
- In IHD, PL-VT only observed with LVEF<40%; in DCM not related to LVEF, induced in 27% with LVEF>40%
Original publication
Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease. Circ Arrhythm Electrophysiol. Published 3 January 2023. doi:10.
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