Heart failure & cardiomyopathies
Proteomic Biomarkers and Pathway Analysis for Progression to Heart Failure in Three Epidemiological Representative Cohorts
Authors' conclusion
In conclusion, our study reinforces the role of NT-proBNP as a key biomarker for asymptomatic cardiac dysfunction and incident HF, consistent with its established use in clinical practice.
Study context
- Population
- Population-based cohorts; association of 92 proteomic biomarkers with left ventricular hypertrophy (LVH), diastolic dysfunction and incident heart failure (HF)three cohorts
- Exposure
- Malmö Preventive Project (MPP) vs STANISLAS vs HOMAGE
- Outcome
- LVH, diastolic dysfunction (DD) and incident HF
- Follow-up
- Median 13 (11-14) years (MPP)
Methodological detailsthree population-based cohorts, case-control (HOMAGE), proteomic chip of 92 biomarkers
- Three population-based cohorts
- Case-control (HOMAGE)
- Proteomic chip of 92 biomarkers
Main finding
As reported in the abstract
NT-proBNP association with LVH, DD and incident HF
Estimate (95% CI)
MPPNT-proBNP, LVH
OR 1.48(1.28–1.71)
MPPNT-proBNP, DD
OR 1.71(1.53–1.92)
MPPNT-proBNP, incident HF
HR 1.98(1.66–2.36)
STANISLASNT-proBNP, LVH
OR 1.20(1.02–1.41)
STANISLASNT-proBNP, DD
OR 1.46(1.12–1.90)
HOMAGENT-proBNP, incident HF
HR 1.85(1.62–2.12)
Observational data: associations, not effects.
Further findings
Outcome frequencies in MPP · median follow-up 13 (11-14) years
- LVH
- 514 (34%)
- Diastolic dysfunction (DD)
- 462 (32.4%)
- Incident HF
- 130 (7.7%)
Outcome frequencies in STANISLAS
- LVH
- 238
- DD
- 76
Other biomarkers and incident HF
- Galectin-4, GDF-15 and ST2 associated with incident HF in MPP and HOMAGE
- Pathway enrichment suggested inflammation and viral infection related to incident HF
Original publication
Proteomic Biomarkers and Pathway Analysis for Progression to Heart Failure in Three Epidemiological Representative Cohorts. Eur J Heart Fail. Published 28 October 2024. doi:10.
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