Heart failure & cardiomyopathies
Protocolized Natriuresis-Guided Decongestion Improves Diuretic Response: The Multicenter ENACT-HF Study
Main finding · NatriuresisResult — go to the resultAdjusted mean ratio 1.64Authors' conclusion
A standardized natriuresis-guided diuretic protocol to guide decongestion in acute heart failure was feasible, safe, and resulted in higher natriuresis and diuresis, as well as a shorter length of stay.
Study context
- Population
- Patients with acute HF and signs of volume overload
- Participants
- 401 patients29 centers18 countries
- Comparison
- Standardized natriuresis-guided diuretic protocol vs standard of care
- Outcome
- Natriuresis
- Follow-up
- 1 day
Methodological detailsinternational
- International
Main finding
As reported in the abstract
Adjusted mean ratio
1.64
P < 0.001
By group
Secondary outcomes
Cumulative natriuresis · 2 days · adjusted for baseline differences
adjusted mean ratio 1.52 · P < 0.001
Cumulative diuresis · 2 days · adjusted for baseline differences
adjusted mean ratio 1.33 · P < 0.001
Length of stay · adjusted for baseline differences
adjusted mean ratio 0.87 · P = 0.036
In-hospital mortality
P = 0.852
In-hospital mortality
- Low and not significantly different between the 2 arms
Original publication
Protocolized Natriuresis-Guided Decongestion Improves Diuretic Response: The Multicenter ENACT-HF Study. Circ Heart Fail. Published 5 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →