Acute cardiac care & resuscitation
Pulmonary Artery Pressures and Mortality During Venoarterial Extracorporeal Membrane Oxygenation (ECMO): An ELSO Registry Analysis
Authors' conclusion
Early on-ECMO right heart function and interval improvement from pre-ECMO values were associated with mortality reduction during cardiac ECMO.
Study context
- Population
- Adults on cardiac venoarterial ECMO, ELSO Registry, 2010–2022
- Participants
- 4,442 ECMO runs
- Exposure
- Pulmonary artery pulse pressure (PAPP) pre-ECMO and on-ECMO in relation to mortality
- Outcome
- In-hospital mortality
Methodological detailsmultivariable-adjusted
- Multivariable-adjusted
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
ΔPAPP (pre-ECMO to on-ECMO), per 2 mm Hg increasemultivariable-adjusted
0.98(0.97–0.99)
P = 0.002On-ECMO PAPP, third quartilegreatest reduction across quartiles
0.75(0.63–0.90)
P = 0.002Per 2 mm Hg increase, as printed
- Overall mortality rate
- 55%
Observational data: associations, not effects.
Further findings
| Outcome | Beta (95% CI) | P value |
|---|---|---|
| Time on ECMO, per 10 mm Hg on-ECMO PAPPLonger time on ECMO | 15 (7.7–21) | P < 0.001 |
Nonsurvivors vs survivors
- Nonsurvivors older, worse SCAI stage, longer pre-ECMO intubation
- P < 0.05 for all
Original publication
Pulmonary Artery Pressures and Mortality During Venoarterial ECMO: An ELSO Registry Analysis. Circ Heart Fail. Published 9 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →