Acute cardiac care & resuscitation

Outcomes With Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Suspected Acute Myocarditis: 10-Year Experience From the Extracorporeal Life Support Organization Registry

Circ Heart FailPublished Retrospective registry cohort study

Authors' conclusion

Compared with all-comers supported with VA-ECMO, in-hospital mortality for patients with acute myocarditis is significantly lower, with nearly two-thirds of patients surviving to discharge.

Study context

Population
Adults with suspected acute myocarditis on peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO), ELSO registry 2011–2020myocarditis cohort
Participants
850 adults
Exposure
Suspected acute myocarditis vs all-comers receiving VA-ECMO
  • Myocarditisn = 850
Outcome
In-hospital mortality
Methodological detailsmulticentre registry (ELSO)
  • Multicentre registry (ELSO)

Main finding

As reported in the abstract

P < 0.001

Observational data: associations, not effects.

Secondary outcomes

Risk factors for in-hospital mortality (multivariable)

Earlier year of support, older age, higher weight, Asian race, need for extracorporeal CPR, sepsis, and lower mean arterial pressure and pH before ECMO

Safety

ECMO complications (bleeding, limb ischemia, infections, ischemic stroke)

More common among nonsurvivors; significantly declined during the study period

Original publication

Outcomes With Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Suspected Acute Myocarditis: 10-Year Experience From the Extracorporeal Life Support Organization Registry. Circ Heart Fail. Published 22 June 2023. doi:10.1161/circheartfailure.122.010152

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