Arrhythmias & electrophysiology
Pulmonary vein narrowing after voltage-guided adjunctive pulmonary vein sleeve pulsed field ablation
Authors' conclusion
In patients undergoing an initial PFA-based PVI, no significant PV narrowing was observed approximately six months after voltage-guided adjunctive PV sleeve PFA using a pentaspline catheter. Further controlled studies with larger populations and longer follow-up are needed to better characterize the safety and clinical utility of this strategy.
Study context
- Population
- Patients who underwent an initial pentaspline pulsed field ablation (PFA)-based PVI for atrial fibrillation with voltage-guided adjunctive pulmonary vein (PV) sleeve PFApatients who underwent an initial pentaspline PFA-based PVI for atrial fibrillation
- Participants
- 147 patients
- Exposure
- Pre-ablation vs approximately six months post-ablation PV cross-sectional area on contrast-enhanced computed tomography
- Outcome
- PVA, post-ablation vs pre-ablation
- Follow-up
- Approximately six months after ablation
Main finding
As reported in the abstract
- Post-ablation PVA was significantly smaller than pre-ablation PVA at all PV sites
Observational data: associations, not effects.
Further findings
Median ΔPVA by PV site · approximately six months after ablation
- Left superior PV
- 5.4%
- Left inferior PV
- 6.4%
- Right superior PV
- 4.6%
- Right inferior PV
- 4.0%
- Difference among the four PV sites
- P = 0.012
Safety
Significant PV narrowing (ΔPVA ≥25%) · approximately six months after ablation
- No significant PV narrowing was observed in this cohort
Original publication
Pulmonary vein narrowing after voltage-guided adjunctive pulmonary vein sleeve pulsed field ablation. Heart Rhythm. Published 22 October 2026. doi:10.
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