Heart failure & cardiomyopathies
A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction
Authors' conclusion
In older obese heart failure with preserved ejection fraction patients, CR+AT produces large improvements in VO2peak and quality-of-life. Adding RT to CR+AT increased leg strength and muscle quality without attenuating skeletal muscle loss or further increasing VO2peak or quality-of-life.
Study context
- Population
- Older patients with chronic HFpEF and body mass index (BMI) ≥28 kg/m²77 completed
- Participants
- 88 patients
- Comparison
- Resistance training (RT)+caloric restriction (CR)+AT vs CR+AT
- Primary endpoint
- VO2peak
- Follow-up
- 20 weeks
Methodological detailssingle-blind
- Single-blind
Primary result
As reported in the abstract
| Group | Value | Within-group P |
|---|---|---|
| RT+CR+AT | 108 (95% CI 958–157) mL/min | P=0.001 |
| CR+AT | 80 (95% CI 30–130) mL/min | P=0.002 |
Value
RT+CR+AT108 (95% CI 958–157) mL/min
CR+AT80 (95% CI 30–130) mL/min
Within-group P
RT+CR+ATP=0.001
CR+ATP=0.002
Further findings
Leg muscle quality increase · 20 weeks · significantly greater with RT+CR+AT
P = 0.04
| Outcome | RT+CR+AT | CR+AT | P value |
|---|---|---|---|
| Weight loss · 20 weeksNonsignificant · mean | −8 (95% CI −9–-7) | −9 (95% CI −11–-8) | P = 0.21 |
| Body fat reduction · 20 weeksNonsignificant | −6.5 (95% CI −7.2–-5.8) kg | −7.4 (95% CI −8.1–-6.7) kg | P = 0.20 |
| Skeletal muscle reduction · 20 weeksNonsignificant | −2.1 (95% CI −2.7–-1.5) kg | −2.1 (95% CI −2.7–-1.4) kg | 0.23 |
| Leg muscle strength increase · 20 weeksSignificantly greater with RT+CR+AT | 4.9 (95% CI 0.7–9.0) Nm | −1.1 (95% CI −5.5–3.2) Nm | P = 0.05 |
Value
RT+CR+AT
17(95% CI 12–22)
CR+AT
23(95% CI 17–28)
- Significant improvement in both (P=0.001 for both); no significant between-group difference
LV mass and arterial stiffness
- Both RT+CR+AT and CR+AT significantly reduced LV mass and arterial stiffness
Safety
- No study-related serious adverse events
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. Published 31 October 2022. doi:10.
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