Aortic & peripheral vascular disease
Randomized Trial of a Vascular Care Team vs Education for Patients With Peripheral Artery Disease
Primary result · Percent change in LDL-CResult — go to the resultLeast-squares mean difference −43.7 % 95% CI −57.6% to −29.9%Authors' conclusion
OPTIMIZE PAD-1 showed that an interprofessional, algorithm-based program can achieve rapid LDL-C lowering in vascular patients using available insurance and therapies, and LDL-C targets can be met in most patients if enabled by optimized systems of care.
Study context
- Population
- Patients with peripheral artery disease (PAD) and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dLrandomized
- Participants
- 114 patients
- Comparison
- Vascular care team vs usual care plus provider education
- Primary endpoint
- Percent change in LDL-C
- Follow-up
- 12 months
Methodological detailsimplementation trial
- Implementation trial
Primary result
As reported in the abstract
Least-squares mean difference
−43.7 %
95% CI −57.6% to −29.9%
P < 0.0001
Change by group
Vascular care team
−49.1
mean change · 95% CI −58.7%–-39.5% · %
Usual care
−5.4
mean change · 95% CI −15.3%–4.6% · %
Vascular care team vs Usual care
least-squares mean difference −43.7 % (95% CI −57.6% to −29.9%); P < 0.0001
Further findings
- Mean LDL-C in vascular care team (baseline, week 4, month 12)
- 100.6 mg/dL · Baseline · Week 4 54.8 mg/dL · Month 12 50.1 mg/dL
Achievement of LDL-C <70 mg/dL and <55 mg/dL · 12 months
- Vascular care team 8 times as likely to achieve LDL-C <55 mg/dL vs usual care
- P < 0.0001
- Vascular care team >3 times as likely to achieve LDL-C <70 mg/dL vs usual care
Original publication
Randomized Trial of a Vascular Care Team vs Education for Patients With Peripheral Artery Disease. J Am Coll Cardiol. Published 25 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it