Incidence and Risk Factors of De Novo Postpartum Hypertension: Understanding Links to Long-Term Cardiovascular Risk
Authors' conclusion
Pregestational diabetes and A2GDM are associated with dnPPHTN. Closer follow-up for BP monitoring postpartum and more urgent transitions of care for ongoing medical management may reduce long-term cardiovascular risk.
Study context
- Population
- Postpartum individuals delivering at a tertiary care institution, excluding those with prepregnancy or antepartum hypertensive disordersincluded participants, of 506 postpartum individuals analyzed
- Participants
- 389 individuals
- Exposure
- Demographic and clinical characteristics of dnPPHTN vs normotensive individuals
- dnPPHTNn = 35
- Outcome
- Incidence of dnPPHTN
- Follow-up
- Up to 6 weeks postpartum
Methodological detailstertiary care institution, over 1 month, adjusted logistic regression models
- Tertiary care institution
- Over 1 month
- Adjusted logistic regression models
Main finding
As reported in the abstract
Developed dnPPHTN, of 389 included participants
35
9.0%
Observational data: associations, not effects.
Further findings
| Outcome | dnPPHTN | Normotensive | Adjusted OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Pregestational diabetes | 5.7% | 0.6% | 11.3 (1.8–73.1) | P = 0.042 | |
| Medication-dependent gestational diabetes mellitus (A2GDM)A2GDM associated with dnPPHTN | 6.1 (1.2–30.1) | ||||
| 0.050.21520Adjusted odds ratio (log scale) |
Early prenatal diastolic BP · higher in the dnPPHTN group · difference did not persist after adjustment
P = 0.008
Original publication
Incidence and Risk Factors of De Novo Postpartum Hypertension: Understanding Links to Long-Term Cardiovascular Risk. JACC Adv. Published 2 May 2025. doi:10.
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