Arrhythmias & electrophysiology
Reduced dementia risk in patients with optimized anticoagulation therapy undergoing atrial fibrillation ablation
Main findingResult — go to the resultHazard ratio 0.44 95% CI 0.22–0.86Authors' conclusion
Catheter ablation of AF in patients with optimized oral anticoagulation therapy was associated with a reduction in dementia diagnosis, even after adjustment for potential confounders and for competing risk of death.
Study context
- Population
- Patients with atrial fibrillation (AF) on optimized oral anticoagulation (Sweden)5,912 ablated vs 52,681 controls
- Participants
- 3,940 vs 3,940
- Exposure
- AF catheter ablation vs medical management
- Catheter ablationn = 3,940
- Controln = 3,940reference
- Outcome
- Dementia diagnosis (ICD codes, patient register)
- Follow-up
- Mean 4.9 ± 2.8 years
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio
0.44
95% CI 0.22–0.86
P = 0.017
Catheter ablationvs Control
HR 0.44 (95% CI 0.22–0.86); P = 0.017
Observational data: associations, not effects.
Further findings
Dementia diagnosis, including patients with prior stroke diagnosis
- Result similar when including patients with a stroke diagnosis before inclusion: HR 0.50 (95% CI 0.28-0.89)
- P = 0.019
Dementia diagnosis, adjusted for competing risk of death
- Result similar after adjustment for competing risk of death: HR 0.41 (95% CI 0.20-0.86)
- P = 0.018
Original publication
Reduced dementia risk in patients with optimized anticoagulation therapy undergoing atrial fibrillation ablation. Heart Rhythm. Published 9 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →