Arrhythmias & electrophysiologyCohort study
REducing INFectiOns thRough Cardiac device Envelope: insight from real world data. The REINFORCE project
- Prospective observational cohort study
- multicentre
- real-world
Authors' conclusion
In our analysis, the use of an absorbable antibiotic-eluting envelope in the general CIED population was associated with a lower risk of systemic and pocket infection.
Study context
- Population
- Patients undergoing cardiac implantable electronic device (CIED) surgery, centres of the One Hospital ClinicalService project
- Participants
- 1,819 patients
- Exposure
- Control vs Envelope
- Controln = 947reference
- Envelopen = 872
- Outcome
- Infection-related clinical events
- Follow-up
- Mean 1.4 years
Main finding
As reported in the abstract
Infection-related events
P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | Envelope | Control | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| 5-year cumulative incidence of infection-related events | 2.1% | 8.1% | 0.34 (0.14–0.80) | P = 0.010 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
REducing INFectiOns thRough Cardiac device Envelope: insight from real world data. The REINFORCE project. Europace. Published 26 July 2023. doi:10.1093/europace/euad224
Summarised from the published abstract; every number is checked against it