Arrhythmias & electrophysiology
Refining prediction of stroke in sinus node dysfunction patients without atrial fibrillation using a P-combined score: a multi-centre study
Authors' conclusion
Chinese ISND patients have a higher IS risk than the general population. Compared with the CHA2DS2-VASc score, the PTFV1-combined CHA2DS2-VASc score shows a better risk-stratification capacity for ISND-related IS.
Study context
- Population
- Patients with isolated sinus node dysfunction (sinus node dysfunction without AF)development n = 1185
- Comparison
- P-combined score vs CHA2DS2-VASc score
- Outcome
- Ischaemic stroke prediction (Harrell's C-statistic)
- Follow-up
- 5-year IS risk
Methodological detailsmulticentre longitudinal cohort, external validation cohort
- Multicentre longitudinal cohort
- External validation cohort
Performance
As reported in the abstract
Harrell's C-statistic for 5-year IS risk · 5 years
| Test or model | C-statistic, development cohort | C-statistic, validation cohort |
|---|---|---|
| CHA2DS2-VASc | 0.678 (0.618-0.738) | 0.747 (0.677-0.816) |
| P-combined score | 0.716 (0.657-0.774) | 0.808 (0.747-0.868) |
C-statistic, development cohort
CHA2DS2-VASc0.678 (0.618-0.738)
P-combined score0.716 (0.657-0.774)
C-statistic, validation cohort
CHA2DS2-VASc0.747 (0.677-0.816)
P-combined score0.808 (0.747-0.868)
- Cut-off value of the score (development cohort); well-discriminated in validation cohort
- 3
Further findings
PTFV1 abnormality and ischaemic stroke (IS)
| Adjusted HR (95% CI) | ||
|---|---|---|
| Abnormal PTFV1Only significantly abnormal P-wave index | 2.56 (1.72–3.80) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
IS incidence, development cohort · median 3.02-year follow-up
- Patients developing IS
- 124 (10.46%)
- IS rate
- 1.63%/year; 95% CI: 1.49-1.78%/year
Original publication
Refining prediction of stroke in sinus node dysfunction patients without atrial fibrillation using a P-combined score: a multi-centre study. Eur J Prev Cardiol. Published 31 August 2023. doi:10.
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