Arrhythmias & electrophysiology
Sick sinus syndrome elevates stroke risk in patients with atrial fibrillation with low CHA2DS2-VASC score
Main finding · Ischemic strokeResult — go to the resultHazard ratio 1.23 95% CI 1.10–1.37Authors' conclusion
SSS independently predicts higher stroke risk in patients with AF, particularly among those with lower baseline CHA2DS2-VASc scores.
Study context
- Population
- Patients with atrial fibrillation (AF), hospital-based cohort, 2010 to 2021
- Participants
- 24,960 patients
- Exposure
- Sick sinus syndrome (SSS) vs no SSS in patients with AF
- SSSn = 1,624
- non-SSSn = 23,336reference
- Outcome
- Ischemic stroke hospitalization
- Follow-up
- Mean 4.07 ± 3.55 years
Methodological detailshospital-based cohort
- Hospital-based cohort
Main finding
Ischemic stroke
Hazard ratio
1.23
95% CI 1.10–1.37
P < 0.001
By group
SSS
4.02% per patient-year
non-SSS
3.03%
SSSvs non-SSS
HR 1.23 (95% CI 1.10–1.37); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Ischemic stroke, by CHA2DS2-VASc score (subgroup)SSSvs non-SSSCHA2DS2-VASc ≤2 | 2.13 (1.76–2.58) | P < 0.001 | |
| Ischemic stroke, by CHA2DS2-VASc score (subgroup)SSSvs non-SSSCHA2DS2-VASc >2 | 1.02 (0.89–1.17) | P = 0.722 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Sick sinus syndrome elevates stroke risk in patients with atrial fibrillation with low CHA2DS2-VASC score. Heart Rhythm. Published 27 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →