Arrhythmias & electrophysiology
Risk of ischemic stroke in sinus node dysfunction with and without atrial fibrillation: Evidence for the presence of a left atrial myopathy in patients with isolated sinus node dysfunction—an analysis of the UK Biobank
Authors' conclusion
SND is an independent risk marker for the development of IS in individuals without AF. This provides further evidence of SND being an electrical marker of a biatrial myopathy.
Study context
- Population
- Individuals aged 40–69 years recruited across the United Kingdom between 2006 and 2010 (UK Biobank), excluding prosthetic heart valves, rheumatic mitral valve diseases, mitral stenosis, and prior ischemic stroke (IS)participants included in this study (median age 57 years, 44.2% male)
- Participants
- 451,493 individuals
- Exposure
- Sinus node dysfunction (SND) and ischemic stroke
- Isolated SNDn = 593
- Combined SND and AFn = 955
- Isolated AFn = 37,065reference
- Controlsn = 412,880reference
- Outcome
- Time to IS
- Follow-up
- Median 13.2 years
Methodological detailsmultivariable competing-risk regression modeling accounting for death
- Multivariable competing-risk regression modeling accounting for death
Main finding
As reported in the abstract
Isolated SND vs controls
Estimate (95% CI)P value
Subdistribution hazard ratio
2.28(1.57–3.31)
P < 0.001Combined SND and AF vs isolated AF
Estimate (95% CI)P value
Subdistribution hazard ratio
1.07(0.84–1.37)
P = 0.58Observational data: associations, not effects.
Original publication
Risk of ischemic stroke in sinus node dysfunction with and without atrial fibrillation: Evidence for the presence of a left atrial myopathy in patients with isolated sinus node dysfunction—an analysis of the UK Biobank. Heart Rhythm. Published 30 April 2025. doi:10.
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