Heart failure & cardiomyopathies
Regional contributions to impaired myocardial mechanical function in heart failure with preserved ejection fraction
Main finding · Regional LV longitudinal strainResult — go to the resultOdds ratio 1.18 CI 1.02–1.37Authors' conclusion
We found that while apical mechanical function is preserved in HHD, it was impaired in HFPEF and may contribute to the transition from an asymptomatic heart disease to a symptomatic heart disease.
Study context
- Population
- Adults with preserved LVEF (≥45%)
- Participants
- 327 adults
- Exposure
- HFpEF vs hypertensive heart disease vs normotensive controls
- Heart failure with preserved ejection fraction (HFPEF)n = 129
- Hypertensive heart disease (HHD)n = 158
- Controlsn = 40reference
- Outcome
- Regional (basal, mid-ventricular, apical) left ventricular (LV) longitudinal strain by echocardiography
Main finding
Regional LV longitudinal strain
Odds ratio
1.18
CI 1.02–1.37
P = 0.030
HFPEFvs HHD
OR 1.18 (CI 1.02–1.37); P = 0.030
As reported in the abstract
- Basal and mid-ventricular deformation more impaired in HHD than controls
- P ≤ 0.003
- Apical deformation more impaired in HFPEF than HHD
- P = 0.005
Observational data: associations, not effects.
Further findings
Discrimination of HFPEF from HHD
- AUC, apical longitudinal strain
- 0.67
- AUC, mid-ventricular longitudinal strain
- 0.59
- AUC, basal longitudinal strain
- 0.60
Original publication
Regional contributions to impaired myocardial mechanical function in heart failure with preserved ejection fraction. Eur Heart J Cardiovasc Imaging. Published 11 April 2023. doi:10.
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