Heart failure & cardiomyopathies
Sex Differences in Efficacy of Multidomain Rehabilitation Among Older Adults With Acute HF: The REHAB-HF Trial
Authors' conclusion
Female (vs male) participants with ADHF had a significantly greater improvement in physical function in response to the REHAB-HF intervention.
Study context
- Population
- Older patients with acute decompensated HF
- Participants
- 349 patients
- Comparison
- REHAB-HF intervention vs attention control, by sex
- Femalen = 183
- Malen = 166reference
- Primary endpoint
- Short Physical Performance Battery (SPPB)
- Follow-up
- 3 months
Methodological detailsprespecified secondary analysis
- Prespecified secondary analysis
Primary result
As reported in the abstract
SPPB, treatment effect by sex (subgroup analysis)
| Group | Effect size |
|---|---|
| Female | 1.9 [95% CI: 1.1-2.7] |
| Male | 1.0 [95% CI: 0.1-1.8] |
Effect size
Female1.9 [95% CI: 1.1-2.7]
Male1.0 [95% CI: 0.1-1.8]
Further findings
| Outcome | Female | Male |
|---|---|---|
| Frailty burden (Fried phenotype), treatment effect by sex · 3 months | ||
| Effect size | −0.5 [95% CI: −0.9 to −0.2] | 0.00 [95% CI: −0.4 to 0.4] |
- Frailty burden (Fried phenotype), treatment effect by sex: P for interaction = 0.04
6MWD and quality of life (QOL) (KCCQ score) · 3 months
- Greater improvement in females vs males, without significant treatment effect interaction by sex
Intervention adherence
- No difference by sex
Original publication
Sex Differences in Efficacy of Multidomain Rehabilitation Among Older Adults With Acute HF: The REHAB-HF Trial. JACC Heart Fail. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →