Heart failure & cardiomyopathies
Sex Differences in Dilated Cardiomyopathy: Evidence Gaps and Future Directions
Authors' conclusion
These findings highlight the influence of sex and genotype on clinical outcomes.
Study context
- Population
- Patients with dilated cardiomyopathy
- Comparison
- Male vs female dilated cardiomyopathy (DCM) patients, by genotype
- Outcome
- Arrhythmic events and HF by sex and genotype
Pooled result
As reported in the abstract
- Men: PLN, DSP and LMNA variant carriers had higher arrhythmic event rates than TTNtv and BAG3 carriers
- Women: RBM20, DSP and PLN variants had the highest arrhythmic risk, TTNtv carriers the lowest
- PLN and LMNA variants had the highest HF risk in both sexes
- BAG3, RBM20 and TTN variants had lower HF rates in female than male carriers
Original publication
Sex Differences in Dilated Cardiomyopathy: Evidence Gaps and Future Directions. J Am Coll Cardiol. Published 26 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →