Relationship Between Control of Cardiovascular Risk Factors and Chronic Kidney Disease Progression, Cardiovascular Disease Events, and Mortality in Chinese Adults
Authors' conclusion
Patients with CKD who had controlled blood pressure, lipids, and glucose showed no excess risk of death, myocardial infarction, or stroke compared to the general population.
Study context
- Population
- Chinese adults with chronic kidney disease (CKD) free of cardiovascular disease (CVD) or end-stage renal disease, Kailuan study20,254 CKD
- Exposure
- CKD with risk factor control vs non-CKD controls
- Non-CKD controlsn = 35,236reference
- Outcome
- MI, stroke, CKD progression and all-cause mortality
- Follow-up
- Median 12.2 to 12.8 years
Methodological detailsmatched cohort
- Matched cohort
Main finding
As reported in the abstract
CKD with all 3 risk factors controlled vs non-CKD controls
CKD, all 3 risk factors controlled vs Non-CKD controlsHazard ratio (95% CI)
MI
0.80(0.56–1.14)
Stroke
0.93(0.78–1.12)
All-cause mortality
1.10(0.98–1.24)
Observational data: associations, not effects.
Further findings
Events during follow-up (all participants) · median follow-up 12.2 to 12.8 years
- Deaths
- 3,875
- Stroke
- 1,888
- MI
- 513
- CKD progression
- 4,825
MI, stroke, CKD progression, all-cause mortality by number of risk factors controlled (CKD)
- Risk factor control associated with lower risk in a dose-dependent manner
Original publication
Relationship Between Control of Cardiovascular Risk Factors and Chronic Kidney Disease Progression, Cardiovascular Disease Events, and Mortality in Chinese Adults. J Am Coll Cardiol. Published 1 October 2024. doi:10.
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