Valvular & structural heart disease
Dysglycaemia and incident aortic stenosis: a cohort study
Authors' conclusion
Dysglycaemia, including glucose levels below the diabetic range, is associated with a higher risk of aortic stenosis.
Study context
- Population
- Participants from the Swedish Apolipoprotein Mortality Risk cohort (1985–1996) free of aortic valve disease at baseline with fasting glucose and lipid levels recorded
- Participants
- 324,449 participants
- Exposure
- Fasting glucose categories compared with normal glucose levels
- Outcome
- Incident aortic stenosis
- Follow-up
- Mean 25.9 years
Main finding
As reported in the abstract
Each group vs normal glucose levelsAdjusted hazard ratio (95% CI)
Low glucose
0.96(0.82–1.13)
Impaired fasting glucose
1.36(1.24–1.50)
High glucose
1.79(1.60–1.99)
Diabetes
2.21(1.80–2.73)
- Participants developed aortic stenosis
- 8523
Observational data: associations, not effects.
Further findings
Spline analysis of glucose and aortic stenosis risk
- Continuous increase in risk with rising glucose levels, even below the impaired fasting glucose threshold
Original publication
Dysglycaemia and incident aortic stenosis: a cohort study. Heart. Published 6 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →